Reinstall the game

: Outdated drivers can lead to "Fatal Error" crashes. Use the NVIDIA Driver Downloads or AMD Driver Support sites to ensure your GPU is up to date.

Reinstall PhysX/middleware included with the game

Troubleshooting the “Failed to Initialize Steam” Fatal Error in Resident Evil 6 : A Technical Analysis of DRM and Runtime Conflicts

Ensure both "Private" and "Public" network boxes are checked for Steam in the "Allow an app through firewall" settings. CARE Toolkit Advanced Solutions Compatibility Mode