Run the patch on a test VM first. While cumulative, some organizations reported that Patch 8 reset custom ribbon configurations. Back up %LOCALAPPDATA%\ESRI\ArcGISPro\Customization\* before deployment.
"Fine," he gritted out. "You win. Patch me." arcgis pro 2.8 patch 8 -2.8.8-
This may be one of the final patches for the 2.8 series. Run the patch on a test VM first