If your game runs fine at the start but slows down as your population hits 50,000, your is the bottleneck, not your graphics card.
[Graphics] UIScale = 1.0 ; lower than 1.0 reduces UI render cost TerrainQualityLevel = 0 ; lowest terrain tessellation WaterQualityLevel = 0 ; disables water reflections ShadowMapResolution = 256 ; default is 1024+ TreesDistance = 0.3 ; reduces tree LOD distance cities skylines settings for low end pc better
This is a magic bullet. It allows the game to render the world at a lower resolution (making it blurry) while keeping the UI sharp. You can scale the resolution down (e.g., to 50%) to gain massive FPS, making the game look like a painting rather than a stuttering mess. If your game runs fine at the start
If you have only 4GB RAM: